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Do not take double or extra doses.<br /> <u>What drug(s) may interact with pioglitazone?<br /> </u>• atorvastatin<br /> • birth control pills or other hormonal methods of birth control<br /> • bosentan<br /> • itraconazole<br /> • ketoconazole<br /> • midazolam<br /> • nifedipine <br /> • other medicines for diabetes, including insulin<br /> • topiramate<br /> <br /> <p><h4> Many medications may cause changes (increase or decrease) in blood sugar, these include:</h4></p> • alcohol containing beverages<br /> • angiotensin converting enzyme inhibitors (ACE inhibitors), often used for high blood pressure or heart problems (examples: captopril, enalapril, lisinopril)<br /> • antiretroviral protease inhibitors (examples: indinavir, ritonavir, saquinavir)<br /> • aspirin and aspirin-like drugs<br /> • baclofen<br /> • beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)<br /> • certain medicines used for mental depression, emotional, or psychotic disturbances<br /> • chromium<br /> • cisapride<br /> • clonidine<br /> • cyclosporine<br /> • diazoxide<br /> • disopyramide<br /> • epinephrine<br /> • female hormones, such as estrogens or progestins, birth control pills<br /> • fibric acid derivatives, used to treat high cholesterol (examples: fenofibrate and gemfibrozil)<br /> • glucagon<br /> • growth hormone (somatropin)<br /> • guanethidine<br /> • isoniazid<br /> • lithium<br /> • metoclopramide<br /> • male hormones or anabolic steroids<br /> • medications to suppress appetite or for weight loss<br /> • medicines for allergies, asthma, cold, or cough<br /> • niacin<br /> • nicotine (including nicotine found in patches and gum)<br /> • octreotide<br /> • pentamidine<br /> • phenytoin<br /> • quinolone antibiotics (examples: ciprofloxacin, levofloxacin, ofloxacin)<br /> • some herbal dietary supplements<br /> • steroid medicines such as prednisone or cortisone<br /> • sulfonamides, medicines for infection (examples: Azulfidine®, Bactrim®, Gantrisin® Septra®) <br /> • tacrolimus<br /> • tegaserod<br /> • thyroid hormones<br /> • water pills (diuretics)<br /> <br /> Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. 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